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2019 CNS Mankhwala Osokoneza Bongo Monosialotetrahexosylganglioside Sodium (GM1) Nkhumba Ubongo (37758-47-7)

2019 CNS Mankhwala Osokoneza Bongo Monosialotetrahexosylganglioside Sodium (GM1) Nkhumba Ubongo (37758-47-7)

Meta Kulongosola

Fufuzani udindo wa GM1 mu thupi laumoyo, zotsutsana ndi kukalamba, ndi zotsatira za chipatala pazochitika zapakati ndi zowopsya.

Kodi Monosialotrahexosylganglioside Solidum (GM1) ndi chiyani?

Sodium ya Monosialotetrahexosylganglioside ndi mchere wokhala ndi tizilombo toyambitsa matenda omwe tanthauzo lake ndilo GM1.

Gululiosides ali m'kalasi yamagulu a ganglio, omwe ali ndi glycosphingolipid okhala ndi asialic acid otsala pa shuga. Chingwe cha silicated polysaccharide chikugwirizanitsa ndi ceramide kudzera ku mgwirizano wa β-glycosidic. Sizimangokhala mkati mwa memphane ya neuronal komanso m'mapangidwe apamtima.

Ngakhale kuti amapanga 0.1% ya ubongo wathunthu, gangliosides amawerengera pafupifupi 10% ya lipids yonse. Zimapangitsa kuti maselo azikhala osiyana, apoptosis, neuroprotection, ndi kutulutsa kwa neurotrophins.

Monosialotetrahexosylganglioside ndi mbali yosavomerezeka yomwe ili ndi chingwe cha oligosaccharide ndi ceramide. Molekyu amasonyeza onse hydrophilic ndi lipophilic katundu. Pokhala wosungunuka m'madzi ndi mafuta, Monosialotetrahexosylganglioside ikhoza kuyenda mosavuta kudzera m'magazi a ubongo.

Sodium ya Monosialotetrahexosylganglioside GM1 imathandiza kwambiri mu ubongo. Imawonetsa zinthu zogwiritsira ntchito mankhwalawa monga kukonzanso kuwonongeka kwa mitsempha, kuyambiranso bwino, ndi kusintha kwa matendawa pambuyo pa kuvulala. Pachifukwachi, sodium ya Monosialotetrahexosylganglioside imathandiza pochiza kuvulaza kwapakati. Zina mwa matenda okhudzana ndi matendawa ndi monga kusokonezeka kwa matenda osokoneza bongo, kuwonongeka kwa mitsempha yambiri, komanso kuvulazidwa kwa mitsempha. Zambiri zimagwiritsidwa ntchito pamene pali mitsempha ya mitsempha.

Mbiri ya Sodium Monosialotetrahexosylganglioside (GM1)

Kuphunzira kwa GM1 ndi udindo wake neuroprotection amabwereranso ku 1970s. Kuchokera nthawi imeneyo, asayansi apeza kafukufuku pamtunduwu pochita zikhalidwe zazing'ono ndi maphunziro a nyama. Zomwe anayeserazo zinayika pakukhazikitsa tanthauzo la GM1 mu matenda osokoneza bongo.

Mu 1986, kudzera mu TRB SA, sodium ya Monosialotetrahexosylganglioside inakhazikitsidwa mwakhama pansi pa dzina la malonda, GM-1. Popeza kuti zotsatira za maphunziro a zinyama zinali zolonjezedwa, ogwira ntchito ku United States anafufuza kufufuza zotsatira za Monosialotetrahexosylganglioside sodium (GM1) pa anthu. Nkhani za phunziroli zinali odwala CNS kuwonongeka chifukwa cha kuvulala kwa msana, kupweteka, matenda a Parkinson, ndi Alzheimer.

Kuchokera apo, akuti Argentina ndi Italy avomereza ntchito yake yothandizira ngati mankhwala ochiritsira mankhwala.

Sodium ya Monosialotetrahexosylganglioside(GM1)Makhalidwe Okhazikika

Msosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba (37758-47-7)

Sodium ya Monosialotetrahexosylganglioside(GM1) zofunika

CHO 37758-47-7
Name mankhwala Msosialotetrahexosylganglioside Sodium (GM1) Nkhumba Ubongo
Dzina la IUPAC (2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-[(E,2R,3S)-3-hydroxy-2-(icosanoylamino)icos-4-enoxyl]-2-(hydroxymethyl)oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Kalasi ya Mankhwala Sphingolipids
Melting Point 207 - 230 ° C
Molecular Formula C77H139N3O31
Mass Mass 1546.841 gmol-1
Kutupa · Madzi
• Kusungunuka pang'ono mu methanol / chloroform
• Zosakanikirana kwambiri ndi mafuta amchere
Maonekedwe Kuyera mpaka woyera wothira mafuta wophika
Chiyeretso 98%
yosungirako Kutentha -20 ° C
Phalala Zaka ziwiri
pH 5.0 kuti 6.5
Mafananidwe · Monosialoganglioside GM1
·Ganglioside GM1

Sodium ya Monosialotetrahexosylganglioside(GM1) Njira yogwira ntchito

Monosialotetrahexosyl ganglioside amagwira ntchito m'njira zingapo. Molekyu ndi chowopsya cha zinthu zambiri za thupi za dongosolo la manjenje.

Mu memphane ya ubongo, ntchito za Monosialotetrahexosylganglioside zimathandiza kuti muyezo wa ion uzikhala mkati ndi kunja kwa minofu. Sikuti imangowonjezera kutengeka, koma imatulutsa mpweya wa sodium ndi calcium ion pump.

Pankhani ya kuvulala kwa mitsempha, Sodium ya Monosialotetrahexosylganglioside (GM1) imabwera kudzateteza mawonekedwe. Amachepetsa ntchito ya phospholipase A2, imayambitsa mphamvu ya calcium ion, ndipo imadula mapangidwe a zowonongeka.

Matenda a ubongo amachulukitsa ntchito ya mapuloteni kinase m'maselo, omwe angakhale ndi udindo wopewera. GM1 imaletsa ndi kubwezeretsa njirayi mwa kuika mphamvu ya mapuloteni mkati mwa cytoplasm ndi phokoso.

Pakati pa mitochondrion, Monosialotetrahexosylganglioside amagwira ntchito yowezeretsa kupanga ATP ndi ntchito yake ya synthase. Zimakonzera kuwonongeka kotheka pa chingwe chotengera cha electron ndipo zimapangitsa kuti phosphorylation ikhale yowonjezera. Zotsatira zake, ubongo wa mitochondrial ntchito umakhala wathanzi.

Minosialotetrahexosylganglioside jekeseni wa sodium imalimbikitsa kukula kwa axonal mwa kuika patsogolo kukula kwa zinthu zomwe zimalandira. Ntchitoyi imayambitsa mitsempha ya mitsempha ndipo imathandizira kuti munthu asinthe matendawa. Pankhani ya kuchepa kwachiwiri, mwinamwake chifukwa cha dopamine neuron kuwonongeka, Monosialotetrahexosylganglioside idzakhazikitsa zotsatira ndi kuonjezera kupulumuka kwa neuroni izi.

2019 CNS Mankhwala Osokoneza Bongo Monosialotetrahexosylganglioside Sodium (GM1) Nkhumba Ubongo (37758-47-7)

Monosialotrahexosylganglioside Solidum (GM1) Zotsatira

Ngakhale kuti ziphuphu ndizochepa m'bongo, ntchito zawo ndizokulu kwambiri. Mamolekyu ameneŵa amathandiza kwambiri kukula, kukonzanso, kukonzanso, ndi kuteteza mitsempha ya mitsempha.

GM1 imachepa ndi msinkhu. Kukalamba kumagwiritsidwa ntchito kwambiri ndi ubongo, chizungulire chowala, kuvulala mwangozi, kapena kukumbukira kukumbukira. Kuwonjezera apo, matenda aakulu akale monga cerebral palsy, stroke, ndi dementia amatha kuwuluka.

Kuwonjezera panthawi yowonjezereka kwa GM1 kumathandiza kuchepetsa zambiri za matenda okalamba. Zina mwa zotsatira zabwino za Monosialotetrahexosylganglioside sodium (GM1) zotsatira zimaphatikizapo kuchiza matenda a Alzheimer, stroke, khunyu, ndi matenda a ubongo. Kuonjezera apo, chowonjezeracho chimachepetsanso ukalamba kukumbukira kukumbukira.

Kugwiritsiridwa ntchito kwa GM1 muzitsulo zamakono ndizambiri. Mwachitsanzo, mayiko angapo a ku Ulaya ndi America akhala akutenga jekeseni wa sodium monosialotetrahexosylganglioside kuti athetse matenda a CNS.

Zowonjezera zimalimbikitsa kukula kwa maselo a mitsempha, kukula kwa ubongo, ndi kupewa matenda a ubongo. Kachirapa, kamolekyu wodabwitsa kwambiri amachititsa matenda a ubongo, kuvulala kwa ischemic, kupha magazi, ndi kuvulala kwa mitsempha.

Chinthu chofunika kwambiri pakuphunzira ndi kugwiritsa ntchito chigawo ichi pa anthu chinali kupeza kuti panalibe zotsatira zoopsa za Monosialotetrahexosyl ganglioside sodium (GM1).

Zotsatira za GM1 sizongoganiza chabe. Mu 1976, Ceccarelli anakhazikitsa kuti magulu oopsa a gangliosides amachititsa kuti mitsempha yatsopano ikhazikitsidwe komanso kukonzanso maselo owonongeka. Kupeza kumeneku kunakhazikitsa maziko olimba a akatswiri omwe adawonetsa chidwi cha ntchito ya GM1 m'katikati mwa manjenje.

Zambiri za mayesero a zachipatala zimatsimikizira kuti Monosialotetrahexosylganglioside imakhudza kwambiri kukula, kusiyana, chitukuko, ndi kubwezeretsedwa kwa maselo a ubongo. Kuwonjezera apo, kafukufuku amatsindika kuti GM1 imachita bwino m'thupi mwachangu, kutsekemera kwa thupi, ndi kusinthasintha kwa syaptic.

Pankhani ya kupwetekedwa mtima, kutenga jekeseni wotchuka wa Monosialotetrahexosylganglioside sodium kumakhudza dongosolo la manjenje m'njira zingapo. Molekyuyo sichidzangowonjezera mbadwo wambiri wa maselo a mitsempha komanso kuwonjezera kuchulukitsa kwawo. Chachiwiri, chowonjezeracho chimathandiza kwambiri pokonzanso, kukonzanso, komanso kugwira ntchito.

Monosialotrahexosyl Ganglioside Solidum (GM1) Njira Yophatikiza

Pakalipano, Monosialotetrahexosyl ganglioside ndi mankhwala okhawo a CNS omwe mwachilengedwe amachitika.

Molekyu ndi chigawo chimodzi cha ganglioside, chomwe chimapangidwa mosapangika mu neural cell membrane ya zinyama. Chifukwa cholemera kwambiri m'matumbo, asayansi ndi ogwira ntchito zachipatala amatha kuzilandira ndi kuzigwiritsa ntchito pokonzekera mankhwalawa a monosialotetrahexose.

Timachotsa monosialotetrahexosyl ganglioside kuchokera kumaselo a mammalian. Ngakhale mutha kupatula kamolekyu kuchokera ku ng'ombe kapena mbuzi, njira yabwino kwambiri ndiyo kuchotsa ubongo wa nkhumba. Chifukwa chake n'chakuti monosialotetrahexosyl yowonongeka kuchokera ku ng'ombe kapena mbuzi nthawi zambiri ikhoza kutulutsa matenda opatsirana monga nthendayi, ndi khunyu.

Zida zopangira ma laboratory za Monosialotetrahexosylganglioside sodium (GM1) zimapezeka, zogwira ntchito, komanso zachuma. Timakupatsani GM1 yotetezeka komanso yodalirika kuchokera ku ubongo wa nkhumba, chifukwa njirayi siimapatsira matenda kwa anthu.

Pa zokolola zambiri, timagwiritsa ntchito njira ya chloroform-methanol-extraction method. Pambuyo pake, timachita kusinthanitsa kwa anion ndi kukula kwake kwachitsulo chromatographic. Kuyeretsa uku kumapangitsa kuti mamolekamo amodzi, omwe ndi> 98% oyera kudzera mwa HPLC.

Kutsiliza

Zotsatira za Monosialotetrahexosyl zowonongeka zimakhala zofunikira mu ntchito zamakono. Ndilo mankhwala ovomerezeka ogwiritsira ntchito mankhwala okhudza matenda a m'maganizo ndi chithandizo cha kuvulaza kwapakati pakati.

Kaya mukufuna kugula GM1 pa ntchito zamagwiritsidwe ntchito kapena kafukufuku, tikukutsimikizirani kuti muli ndi mankhwala apamwamba. Ife timatulutsa-kutulutsa Monosialotetrahexosylganglioside sodium (GM1) powder pansi pa miyezo yoyenera yoyendetsera khalidwe.

Zothandizira

  1. Schneider, JS, Roeltgen, DP, ndi al. (1998). Matenda a Parkinson: Ntchito Yowonjezereka Ndi Matenda a GM1 Ganglioside mu Phunziro Lokhazikitsidwa ndi Malo Okhazikika.
  2. Bansal, AS, Abdul-Karim, B., Malik, RA, et al. (1994). Matenda a IgM Ganglioside GM1 Odwala ndi Matenda Odzidzimutsa Kapena Matenda a Mitsempha, ndi Olamulira. Journal Clinical Pathology.
  3. Mocchetti, I. (2005). Magulu a Gangliosides, Malasitiki a Neuronal ndi Repair, ndi Neurotrophins.
  4. Aureli, M., Mauri, L., Ciampa, MG, Prinetti, A., Toffano, G., et al. (2016). GM1 Ganglioside: Maphunziro Akale ndi Tsogolo Labwino. Molecular Neurobiology.
  5. Bian, L., Yang, J., ndi Sun, Y. (2015). Kusungunula ndi Kuyeretsa kwa Monosialotetrahexosylgangliosides kuchokera ku Nkhumba Ubongo ndi Kukhetsa ndi Madzi Akupanga Chromatography.